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The antibody against CALCA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 26-128 of CALCA (NP_001029125.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
The antibody against CALCA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 26-128 of CALCA (NP_001029125.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
Immunohistochemistry analysis of CALCA in paraffin-embedded mouse spinal cord using CALCA Rabbit pAb at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
| Cat.No | ADA-01678A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CALCA |
| Target Synonyms | CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I; CGRP-alpha; CALCA | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 26-128 of CALCA (NP_001029125.1). | Immunogen Sequence | APFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRRRDLQA |
|---|---|---|---|
| Uniprot ID | P06881 |
Uniprot Id
P06881
Target Species
Human
Target Name
CALCA
Target Full Name
Calcitonin gene-related peptide 1
Target Function
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
Target Subcellular Location
Secreted.
Target Protein Families
Calcitonin family
Target Research Area
Signal Transduction
Target Synonyms
CALCA; CALC1Calcitonin gene-related peptide 1; Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I
Target Background
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
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