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The antibody against NCALD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human NCALD (NP_114430.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against NCALD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human NCALD (NP_114430.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01827A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NCALD |
| Target Synonyms | NCALD | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, A-549, BT-474, Mouse brain, Mouse liver, Mouse lung, Mouse spinal cord, THP-1 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human NCALD (NP_114430.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNRDGKLSLEEFIRGAKSDPSIVRLLQCDPSSAGQF | Uniprot ID | P61601 |
Uniprot Id
P61601
Target Species
Human
Target Name
NCALD
Target Full Name
Neurocalcin-delta
Target Function
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
Target Protein Families
Recoverin family
Target Tissue Specificity
Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.
Target Research Area
Neuroscience
Target Synonyms
NCALD; Neurocalcin-delta
Target Background
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined.
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