Rabbit anti-Human PPIH Polyclonal Antibody

The antibody against PPIH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-177 of human PPIH (NP_006338.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-02284A

Number

Cat.No	ADA-02284A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PPIH
Target Synonyms	CYPH; CYP-20; USA-CYP; SnuCyp-20; PPIH	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HepG2, Rat kidney, Rat testis	Application	ELISA, WB

Cat.No

ADA-02284A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PPIH

Target Synonyms

CYPH; CYP-20; USA-CYP; SnuCyp-20; PPIH

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HepG2, Rat kidney, Rat testis

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-177 of human PPIH (NP_006338.1).	Target Species	Human
Immunogen Sequence	MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM	Uniprot ID	O43447

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-177 of human PPIH (NP_006338.1).

Target Species

Human

Immunogen Sequence

MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM

Uniprot ID

O43447

Background Information

Uniprot Id

O43447
Target Species

Human
Target Name

PPIH
Target Full Name

Peptidyl-prolyl cis-trans isomerase H
Target Function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.
Target Subcellular Location

Nucleus speckle. Cytoplasm. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.
Target Protein Families

Cyclophilin-type PPIase family, PPIase H subfamily
Target Synonyms

Cyclophilin H; CYP-20; CypH; Peptidyl prolyl cis trans isomerase H; Peptidyl-prolyl cis-trans isomerase H; Peptidylprolyl isomerase H; PPIase H; PPIH; PPIH_HUMAN; RGD1564921; Rotamase H; Small nuclear ribonucleoprotein particle specific cyclophilin H; Small nuclear ribonucleoprotein particle-specific cyclophilin H; SnuCyp 20; U snRNP associated cyclophilin SnuCyp 20; U-snRNP-associated cyclophilin SnuCyp-20; USA CYP; USA-CYP; USACYP
Target Background

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.

Rabbit anti-Human PPIH Polyclonal Antibody

Specifications

Immunogen Information

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