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The antibody against CHN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CHN1 (NP_001813.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CHN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CHN1 (NP_001813.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02437A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CHN1 |
| Target Synonyms | NC; CHN; DURS2; ARHGAP2; RHOGAP2; CHN1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, BT-474, Jurkat, MCF7, Mouse brain, Mouse spinal cord, Mouse testis, SH-SY5Y | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CHN1 (NP_001813.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIP | Uniprot ID | P15882 |
Uniprot Id
P15882
Target Species
Human
Target Name
CHN1
Target Full Name
N-chimaerin
Target Function
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Target Involvement
Duane retraction syndrome 2 (DURS2)
Target Tissue Specificity
In neurons in brain regions that are involved in learning and memory processes.
Target Synonyms
A-chimaerin; Alpha-chimerin; ARHGAP2; CHIN_HUMAN; CHN; Chn1; N chimaerin; N chimerin; N-chimaerin; N-chimerin; NC; Rho GTPase-activating protein 2; RHOGAP2
Target Background
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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