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The antibody against GNS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 293-552 of human GNS (NP_002067.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GNS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 293-552 of human GNS (NP_002067.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02477A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GNS |
| Target Synonyms | G6S; GNS | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, Rat brain, 293T, BT-474, Mouse liver, Mouse spleen, NCI-H460, SKOV3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 293-552 of human GNS (NP_002067.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P15586 | Immunogen Sequence |
Uniprot Id
P15586
Target Species
Human
Target Name
GNS
Target Full Name
N-acetylglucosamine-6-sulfatase
Target Involvement
Mucopolysaccharidosis 3D (MPS3D)
Target Subcellular Location
Lysosome.
Target Protein Families
Sulfatase family
Target Synonyms
2610016K11Rik; AU042285; C87209; G6S; Glucosamine (N-acetyl) 6 sulfatase; Glucosamine 6 sulfatase; Glucosamine-6-sulfatase; GNS; GNS_HUMAN; MGC21274; N acetylglucosamine 6 sulfatase [Precursor]; N-acetylglucosamine-6-sulfatase; N28088
Target Background
The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.
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