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The antibody against CAPN5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 361-640 of human CAPN5 (NP_004046.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against CAPN5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 361-640 of human CAPN5 (NP_004046.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-02514A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CAPN5 |
| Target Synonyms | VRNI; ADNIV; HTRA3; nCL-3; CAPN5 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain, Mouse spinal cord, Mouse thymus, SKOV3 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 361-640 of human CAPN5 (NP_004046.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O15484 | Immunogen Sequence |
Uniprot Id
O15484
Target Species
Human
Target Name
CAPN5
Target Full Name
Calpain-5
Target Function
Calcium-regulated non-lysosomal thiol-protease.
Target Involvement
Vitreoretinopathy, neovascular inflammatory (VRNI)
Target Protein Families
Peptidase C2 family
Target Tissue Specificity
Expressed in many tissues. Strong expression in the photoreceptor cells of the retina, with a punctate pattern of labeling over the nuclei and inner segments with less expression along the other segments and outer plexiform layer.
Target Synonyms
ADNIV; Calpain htra 3; Calpain htra-3; Calpain-5; CAN5_HUMAN; CAPN 5; Capn5; nCL 3; nCL-3; New calpain 3; VRNI
Target Background
Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.
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