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The antibody against PMS1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 405-619 of human PMS1 (NP_000525.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PMS1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 405-619 of human PMS1 (NP_000525.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04388A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PMS1 |
| Target Synonyms | MLH2; PMSL1; hPMS1; HNPCC3; PMS1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HL-60, HT-1080, MCF7 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 405-619 of human PMS1 (NP_000525.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P54277 | Immunogen Sequence |
Uniprot Id
P54277
Target Species
Human
Target Name
PMS1
Target Full Name
PMS1 protein homolog 1
Target Function
Probably involved in the repair of mismatches in DNA.
Target Subcellular Location
Nucleus.
Target Protein Families
DNA mismatch repair MutL/HexB family
Target Synonyms
DNA mismatch repair protein PMS1; FLJ98259; HNPCC3; hPMS1; Human homolog of yeast mutL; Mismatch repair gene PMSL1; pms1; PMS1 postmeiotic segregation increased 1 (S. cerevisiae); PMS1 postmeiotic segregation increased 1; PMS1 protein homolog 1; PMS1_HUMAN; PMSL1; Rhabdomyosarcoma antigen MU RMS 40.10B; Rhabdomyosarcoma antigen MU RMS 40.10E
Target Background
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.
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