Rabbit anti-Human NEK1 Polyclonal Antibody

Uniprot Id

Q96PY6

Target Species

Human

Target Name

NEK1

Target Full Name

Serine/threonine-protein kinase Nek1

Target Function

Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly.

Target Involvement

Short-rib thoracic dysplasia 6 with or without polydactyly (SRTD6)

Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm.

Target Protein Families

Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily

Target Tissue Specificity

High fetal expression in the brain and kidney.

Target Synonyms

DKFZp686D06121; DKFZp686K12169; kat; KIAA1901; MGC138800; MGC189817; NEK1; NEK1_HUMAN; Never in mitosis A-related kinase 1; Never in mitosis gene A-related kinase 1; NIMA (never in mitosis gene a)-related kinase 1; NIMA-related kinase 1; NimA-related protein kinase 1; NY-REN-55; OTTHUMP00000219432; OTTHUMP00000219433; OTTHUMP00000219434; OTTHUMP00000219435; Protein-serine/threonine kinase; Renal carcinoma antigen NY-REN-55; Serine/threonine-protein kinase Nek1; SRPS2; SRPS2A; SRTD6

Target Background

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.