Rabbit anti-Human PROCR Polyclonal Antibody

Uniprot Id

Q9UNN8

Target Species

Human

Target Name

PROCR

Target Full Name

Endothelial protein C receptor

Target Function

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Target Research Area

Cardiovascular

Target Synonyms

Activated protein C receptor; APC receptor; APCR; bA42O4.2; CCCA ; CCD41; CD201; CD201 antigen ; cell cycle; centrosome-associated protein; Cell cycle; centrosome-associated protein; centrocyclin; Endothelial cell protein C receptor; Endothelial protein C receptor; EPCR; EPCR_HUMAN; MGC23024; PROCR; Protein C receptor; endothelial

Target Background

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer.