Rabbit anti-Human Tubulin beta-1 chain Polyclonal Antibody

Uniprot Id

Q9H4B7

Target Species

Human

Target Name

TUBB1

Target Full Name

Tubulin beta-1 chain

Target Function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Target Involvement

Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1)

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

Tubulin family

Target Tissue Specificity

Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.

Target Synonyms

2810484G07Rik; beta 1 tubulin; Beta tubulin 1, class VI; Beta-tubulin; Class VI beta tubulin; dJ543J19.4; M(beta)1; TBB1_HUMAN; TUBB1; Tubulin beta 1 class VI; Tubulin beta-1 chain; Tubulin, beta 1; tubulin, beta1

Target Background

This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.