Rabbit anti-Human PDE4A Polyclonal Antibody

Uniprot Id

P27815

Target Species

Human

Target Name

PDE4A

Target Full Name

3',5'-cyclic-AMP phosphodiesterase 4A

Target Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Target Subcellular Location

[Isoform 1]: Cytoplasm, perinuclear region.; [Isoform 2]: Cytoplasm, perinuclear region. Cell projection, ruffle membrane.; [Isoform 4]: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes.; [Isoform 6]: Cytoplasm, perinuclear region.; [Isoform 7]: Cytoplasm. Membrane. Note=Predominantly cytoplasmic.

Target Protein Families

Cyclic nucleotide phosphodiesterase family, PDE4 subfamily

Target Tissue Specificity

Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Iso

Target Synonyms

PDE4; DPDE2; PDE46; PDE4A

Target Background

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.