Rabbit anti-Human PNRC2 Polyclonal Antibody

The antibody against PNRC2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNRC2 (NP_060231.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-08728A

Number

Cat.No	ADA-08728A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PNRC2
Target Synonyms	PNRC2	Form	Liquid
Species Reactivity	Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse lung	Application	ELISA, WB

Cat.No

ADA-08728A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PNRC2

Target Synonyms

PNRC2

Form

Liquid

Species Reactivity

Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse lung

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNRC2 (NP_060231.1).	Target Species	Human
Immunogen Sequence	MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKERGHGYNSSAAAWQAMQNGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSE	Uniprot ID	Q9NPJ4

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNRC2 (NP_060231.1).

Target Species

Human

Immunogen Sequence

MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKERGHGYNSSAAAWQAMQNGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSE

Uniprot ID

Q9NPJ4

Background Information

Uniprot Id

Q9NPJ4
Target Species

Human
Target Name

PNRC2
Target Full Name

Proline-rich nuclear receptor coactivator 2
Target Function

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.
Target Subcellular Location

Nucleus. Cytoplasm, P-body.
Target Protein Families

PNRC family, PNRC2 subfamily
Target Tissue Specificity

Expressed in heart, lung, muscle and brain.
Target Synonyms

0610011E17Rik; D4Bwg0593e; FLJ20312; MGC11707; MGC93828; MGC99541; OTTMUSP00000010360; OTTMUSP00000010366; pnrc2; PNRC2_HUMAN; Proline rich nuclear receptor coactivator 2; Proline-rich nuclear receptor coactivator 2; RP11-4M23.5; RP23-161N17.3
Target Background

Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in Golgi apparatus; P-body; and nucleoplasm.

Rabbit anti-Human PNRC2 Polyclonal Antibody

Specifications

Immunogen Information

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