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The antibody against CACNA1E was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CACNA1E was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09008A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CACNA1E |
| Target Synonyms | BII; CACH6; DEE69; gm139; Cav2.3; EIEE69; CACNL1A6; CACNA1E | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, 293T, Mouse brain, Mouse liver, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q15878 | Immunogen Sequence |
Uniprot Id
Q15878
Target Species
Human
Target Name
CACNA1E
Target Full Name
Voltage-dependent R-type calcium channel subunit alpha-1E
Target Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1E subfamily
Target Tissue Specificity
Expressed in neuronal tissues and in kidney.
Target Synonyms
alpha-1 polypeptide; BII; Brain calcium channel II; CAC 1E; CAC1E; CAC1E_HUMAN; CACH 6; CACH6; CACNA1E; Cacnl1 a6; CACNL1A6; Calcium channel; Calcium channel; L type; alpha 1 polypeptide; isoform 6; calcium channel; R type; Cav 2.3; Cchra 1; Cchra1; isoform 6; L type; Voltage dependent R type calcium channel subunit alpha 1E; Voltage gated calcium channel subunit alpha Cav2.3; Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-gated calcium channel subunit alpha Cav2.3
Target Background
Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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