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The antibody against AADAC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 170-399 of human AADAC (NP_001077.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against AADAC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 170-399 of human AADAC (NP_001077.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09048A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AADAC |
| Target Synonyms | DAC; CES5A1; AADAC | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, Mouse liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 170-399 of human AADAC (NP_001077.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P22760 | Immunogen Sequence |
Uniprot Id
P22760
Target Species
Human
Target Name
AADAC
Target Full Name
Arylacetamide deacetylase
Target Function
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
Target Protein Families
'GDXG' lipolytic enzyme family
Target Tissue Specificity
Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.
Target Research Area
Signal Transduction
Target Synonyms
AAAD_HUMAN; Aada; Aadac; Arylacetamide deacetylase (esterase); Arylacetamide deacetylase; CES5A1; DAC
Target Background
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens
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