Rabbit anti-Human Histone H1.4 Polyclonal Antibody

The antibody against Histone H1.4 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human Histone H14 (NP_005312.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-10530A

Number

Cat.No	ADA-10530A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Histone H1.4
Target Synonyms	H1E; H1.4; H1F4; RMNS; H1s-4; HIST1H1E; dJ221C16.5; Histone H1.4	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse liver, Rat liver	Application	ELISA, WB

Cat.No

ADA-10530A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Histone H1.4

Target Synonyms

H1E; H1.4; H1F4; RMNS; H1s-4; HIST1H1E; dJ221C16.5; Histone H1.4

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse liver, Rat liver

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Histone H14 (NP_005312.1).	Target Species	Human
Immunogen Sequence	MSETAPAAPAAPAPAEKTPVKKKARKSAGAAKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTG	Uniprot ID	P10412

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Histone H14 (NP_005312.1).

Target Species

Human

Immunogen Sequence

MSETAPAAPAAPAPAEKTPVKKKARKSAGAAKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTG

Uniprot ID

P10412

Background Information

Uniprot Id

P10412
Target Species

Human
Target Name

H1-4
Target Full Name

Histone H1.4
Target Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
Target Involvement

Rahman syndrome (RMNS)
Target Subcellular Location

Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus.
Target Protein Families

Histone H1/H5 family
Target Synonyms

H1 histone family member 4; H1.4; H14_HUMAN; H1E; H1F4; Hist1h1e; Histone 1 H1e; Histone cluster 1 H1e; Histone H1; Histone H1.4; Histone H1B; MGC116819
Target Background

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Rabbit anti-Human Histone H1.4 Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human Histone H1.4 Polyclonal Antibody Now

Related Products