Rabbit anti-Human AARS Polyclonal Antibody

The antibody against AARS was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human AARS (P49588) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01908A

Number

Cat.No	ADA-01908A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	AARS
Target Synonyms	AARS; TTD8; CMT2N; DEE29; HDLS2; EIEE29	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, HepG2, MCF7, Mouse brain, Mouse liver, Rat spinal cord, SW620, U-251MG	Application	ELISA, WB

Cat.No

ADA-01908A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

AARS

Target Synonyms

AARS; TTD8; CMT2N; DEE29; HDLS2; EIEE29

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, HepG2, MCF7, Mouse brain, Mouse liver, Rat spinal cord, SW620, U-251MG

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AARS (P49588).	Target Species	Human
Immunogen Sequence	MDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEM	Uniprot ID	P49588

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AARS (P49588).

Target Species

Human

Immunogen Sequence

MDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEM

Uniprot ID

P49588

Background Information

Uniprot Id

P49588
Target Species

Human
Target Name

AARS1
Target Full Name

Alanine--tRNA ligase, cytoplasmic
Target Function

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Target Involvement

Charcot-Marie-Tooth disease 2N (CMT2N); Epileptic encephalopathy, early infantile, 29 (EIEE29)
Target Subcellular Location

Cytoplasm.
Target Protein Families

Class-II aminoacyl-tRNA synthetase family
Target Synonyms

AARS; AI316495; Alanine tRNA ligase 1, cytoplasmic; Alanine tRNA ligase; Alanine tRNA ligase cytoplasmic; Alanine--tRNA ligase; Alanyl tRNA synthetase; Alanyl tRNA synthetase cytoplasmic; Alanyl-tRNA synthetase; AlaRS; C76919; CMT2N; cytoplasmic; EC 6.1.1.7; MGC37368; Renal carcinoma antigen NY REN 42; Renal carcinoma antigen NY-REN-42; SYAC_HUMAN
Target Background

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.

Rabbit anti-Human AARS Polyclonal Antibody

Specifications

Immunogen Information

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