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The antibody against ABHD6 was raised in Rabbit using the recombinant protein of human ABHD6 as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ABHD6 was raised in Rabbit using the recombinant protein of human ABHD6 as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of various lysates, using ABHD6 Rabbit pAb at 1:500 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
| Cat.No | ADA-08097A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ABHD6 |
| Target Synonyms | AA673485; AV065425; 0610041D24Rik; ABHD6 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | C6, C2C12, RAW264.7 | Application | ELISA, WB |
| Immunogen Description | Recombinant protein of human ABHD6. | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BV23 | Immunogen Sequence |
Uniprot Id
Q9BV23
Target Species
Human
Target Name
ABHD6
Target Full Name
Monoacylglycerol lipase ABHD6
Target Function
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.
Target Subcellular Location
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Mitochondrion membrane; Single-pass type II membrane protein.
Target Protein Families
AB hydrolase superfamily
Target Synonyms
ABHD6Monoacylglycerol lipase ABHD6; EC 3.1.1.23; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6
Target Background
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycerophosphate (BMP and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.
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