Rabbit anti-Human ACOX2 Polyclonal Antibody

The antibody against ACOX2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ACOX2 (NP_003491.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-11139A

Number

Cat.No	ADA-11139A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ACOX2
Target Synonyms	BCOX; BRCOX; CBAS6; THCCox; BRCACOX; ACOX2	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, 293T, 293T-ACOX2-N	Application	ELISA, WB, IHC-P

Cat.No

ADA-11139A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ACOX2

Target Synonyms

BCOX; BRCOX; CBAS6; THCCox; BRCACOX; ACOX2

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, 293T, 293T-ACOX2-N

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ACOX2 (NP_003491.1).	Target Species	Human
Immunogen Sequence	MGSPVHRVSLGDTWSRQMHPDIESERYMQSFDVERLTNILDGGAQNTALRRKVESIIHSYPEFSCKDNYFMTQNERYKAAMRRAFHIRLIARRLGWLEDGRELGYAYRALSGDVALNIHRVFVRALRSLGSEEQIAKWDPLCKNIQIIAT	Uniprot ID	Q99424

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ACOX2 (NP_003491.1).

Target Species

Human

Immunogen Sequence

MGSPVHRVSLGDTWSRQMHPDIESERYMQSFDVERLTNILDGGAQNTALRRKVESIIHSYPEFSCKDNYFMTQNERYKAAMRRAFHIRLIARRLGWLEDGRELGYAYRALSGDVALNIHRVFVRALRSLGSEEQIAKWDPLCKNIQIIAT

Uniprot ID

Q99424

Background Information

Uniprot Id

Q99424
Target Species

Human
Target Name

ACOX2
Target Full Name

Peroxisomal acyl-coenzyme A oxidase 2
Target Function

Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. Capable of oxidizing short as well as long chain 2-methyl branched fatty acids.
Target Involvement

Congenital bile acid synthesis defect 6 (CBAS6)
Target Subcellular Location

Peroxisome.
Target Protein Families

Acyl-CoA oxidase family
Target Tissue Specificity

Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.
Target Synonyms

12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; 3 alpha 7 alpha 12 alpha trihydroxy 5 beta cholestanoyl CoA oxidase; 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholestanoyl CoA 24 hydroxylase; 3-alpha; 7-alpha; ACOX 2; ACOX2; ACOX2_HUMAN; Acyl CoA oxidase 2; Acyl Coenzyme A oxidase 2; Acyl Coenzyme A oxidase 2 branched chain; Acyl coenzyme A oxidase 2 peroxisomal; BCOX; BRCACOX; BRCOX; Peroxisomal acyl-coenzyme A oxidase 2; Peroxisomal branched chain acyl CoA oxidase; THCA CoA oxidase; THCA-CoA oxidase; THCCox; Trihydroxycoprostanoyl CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase
Target Background

The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children.

Rabbit anti-Human ACOX2 Polyclonal Antibody

Specifications

Immunogen Information

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