Rabbit anti-Human ACVR1C Polyclonal Antibody

Uniprot Id

Q8NER5

Target Species

Human

Target Name

ACVR1C

Target Full Name

Activin receptor type-1C

Target Function

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily

Target Tissue Specificity

Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.

Target Synonyms

Activin A receptor; type IC; Activin receptor like kinase 7; Activin receptor type 1C precursor; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR IC; ACTR-IC; ACTRIC; ACV1C_HUMAN; Acvr1c; ACVRLK7; ALK 7; ALK-7; ALK7

Target Background

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).