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The antibody against ALKBH4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human ALKBH4 (NP_060091.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against ALKBH4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human ALKBH4 (NP_060091.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
Immunofluorescence analysis of A549 cells using ALKBH4 antibody. Blue: DAPI for nuclear staining.
| Cat.No | ADA-06311A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ALKBH4 |
| Target Synonyms | ABH4; ALKBH4 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human ALKBH4 (NP_060091.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NXW9 | Immunogen Sequence |
Uniprot Id
Q9NXW9
Target Species
Human
Target Name
ALKBH4
Target Full Name
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4
Target Function
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
Target Subcellular Location
Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
Target Protein Families
AlkB family
Target Tissue Specificity
Widely expressed, with highest expression in pancreas, ovary and spleen.
Target Synonyms
2010004B12Rik; ABH4; Abj4; AlkB; alkylation repair homolog 4 (E. coli); ALKB4_HUMAN; Alkbh4; Alkylated DNA repair protein alkB homolog 4; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; FLJ20013; Probable alpha-ketoglutarate dependent dioxygenase ABH4; RGD1308608
Target Background
Enables 2-oxoglutarate-dependent dioxygenase activity and actin binding activity. Involved in actomyosin structure organization; cleavage furrow ingression; and protein demethylation. Located in contractile ring and midbody.
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