Rabbit anti-Human ALKBH4 Polyclonal Antibody

The antibody against ALKBH4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ALKBH4 (NP_060091.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-09186A

Number

Cat.No	ADA-09186A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ALKBH4
Target Synonyms	ABH4; ALKBH4	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	MCF7, NCI-H125, SKOV3	Application	ELISA, WB

Cat.No

ADA-09186A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ALKBH4

Target Synonyms

ABH4; ALKBH4

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

MCF7, NCI-H125, SKOV3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ALKBH4 (NP_060091.1).	Target Species	Human
Immunogen Sequence	MAAAAAETPEVLRECGCKGIRTCLICERQRGSDPPWELPPAKTYRFIYCSDTGWAVGTEESDFEGWAFPFPGVMLIEDFVTREEEAELVRLMDRDPWKLSQSGRRKQDYGPKVNFRKQKLKTEGFCGLPSFSREVVRRMGLYPGLEGFRPVEQCNLDYCPERGSAIDPHL	Uniprot ID	Q9NXW9

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ALKBH4 (NP_060091.1).

Target Species

Human

Immunogen Sequence

MAAAAAETPEVLRECGCKGIRTCLICERQRGSDPPWELPPAKTYRFIYCSDTGWAVGTEESDFEGWAFPFPGVMLIEDFVTREEEAELVRLMDRDPWKLSQSGRRKQDYGPKVNFRKQKLKTEGFCGLPSFSREVVRRMGLYPGLEGFRPVEQCNLDYCPERGSAIDPHL

Uniprot ID

Q9NXW9

Background Information

Uniprot Id

Q9NXW9
Target Species

Human
Target Name

ALKBH4
Target Full Name

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4
Target Function

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
Target Subcellular Location

Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
Target Protein Families

AlkB family
Target Tissue Specificity

Widely expressed, with highest expression in pancreas, ovary and spleen.
Target Synonyms

2010004B12Rik; ABH4; Abj4; AlkB; alkylation repair homolog 4 (E. coli); ALKB4_HUMAN; Alkbh4; Alkylated DNA repair protein alkB homolog 4; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; FLJ20013; Probable alpha-ketoglutarate dependent dioxygenase ABH4; RGD1308608
Target Background

Enables 2-oxoglutarate-dependent dioxygenase activity and actin binding activity. Involved in actomyosin structure organization; cleavage furrow ingression; and protein demethylation. Located in contractile ring and midbody.

Rabbit anti-Human ALKBH4 Polyclonal Antibody

Specifications

Immunogen Information

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