Rabbit anti-Human Arp2 Polyclonal Antibody

The antibody against Arp2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Arp2 (NP_005713.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-10797A

Number

Cat.No	ADA-10797A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Arp2
Target Synonyms	ARP2; Arp2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	C6, HeLa, 293T, HepG2, Mouse brain, Mouse lung, Mouse spleen, Rat kidney, THP-1	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-10797A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Arp2

Target Synonyms

ARP2; Arp2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

C6, HeLa, 293T, HepG2, Mouse brain, Mouse lung, Mouse spleen, Rat kidney, THP-1

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Arp2 (NP_005713.1).	Target Species	Human
Immunogen Sequence	MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSG	Uniprot ID	P61160

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Arp2 (NP_005713.1).

Target Species

Human

Immunogen Sequence

MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSG

Uniprot ID

P61160

Background Information

Uniprot Id

P61160
Target Species

Human
Target Name

ACTR2
Target Full Name

Actin-related protein 2
Target Function

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Target Protein Families

Actin family, ARP2 subfamily
Target Synonyms

Actin like protein 2; Actin related protein 2; Actin-like protein 2; Actin-related protein 2; ACTR2; ARP2 actin related protein 2 homolog (yeast); ARP2; ARP2/3 COMPLEX; ARP2_HUMAN; OTTHUMP00000159937; OTTHUMP00000202270
Target Background

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human Arp2 Polyclonal Antibody

Specifications

Immunogen Information

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