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The antibody against ASCC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 488-757 of human ASCC2 (NP_115580.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ASCC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 488-757 of human ASCC2 (NP_115580.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06036A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ASCC2 |
| Target Synonyms | p100; ASC1p100; ASCC2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, A-431, HepG2, HT-29, Mouse eye, Rat pancreas | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 488-757 of human ASCC2 (NP_115580.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H1I8 | Immunogen Sequence |
Uniprot Id
Q9H1I8
Target Species
Human
Target Name
ASCC2
Target Full Name
Activating signal cointegrator 1 complex subunit 2
Target Function
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes.
Target Subcellular Location
Nucleus. Nucleus speckle.
Target Protein Families
ASCC2 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
1700011I11Rik; 2610034L15Rik; Activating signal cointegrator 1 complex subunit 2; AI482016; ASC 1 complex subunit p100; ASC-1 complex subunit p100; ASC1P100; ASCC 2; Ascc2; ASCC2_HUMAN; AW046480; FLJ21588; OTTMUSP00000005258; p100; RGD1561422; RP23-280J3.3; Trip4 complex subunit p100
Target Background
Predicted to enable ubiquitin binding activity. Involved in regulation of transcription, DNA-templated; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of activating signal cointegrator 1 complex.
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