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The antibody against ASTL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 24-431 of human ASTL (NP_001002036.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ASTL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 24-431 of human ASTL (NP_001002036.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05329A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ASTL |
| Target Synonyms | SAS1B; OOMD11; OZEMA11; ASTL | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 24-431 of human ASTL (NP_001002036.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6HA08 | Immunogen Sequence |
Uniprot Id
Q6HA08
Target Species
Human
Target Name
ASTL
Target Full Name
Astacin-like metalloendopeptidase
Target Function
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
Target Subcellular Location
Cytoplasm. Cell membrane. Cytoplasmic vesicle, secretory vesicle, Cortical granule.
Target Protein Families
Peptidase M12A family
Target Tissue Specificity
Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues.
Target Research Area
Signal Transduction
Target Synonyms
ASTLAstacin-like metalloendopeptidase; EC 3.4.-.-; Oocyte astacin; Ovastacin
Target Background
Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Predicted to be located in cortical granule and plasma membrane.
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