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The antibody against BRF2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 180-419 of human BRF2 (NP_060780.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BRF2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 180-419 of human BRF2 (NP_060780.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-08944A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BRF2 |
| Target Synonyms | BRFU; TFIIIB50; BRF2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | C6, Mouse testis, Rat lung | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 180-419 of human BRF2 (NP_060780.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9HAW0 | Immunogen Sequence |
Uniprot Id
Q9HAW0
Target Species
Human
Target Name
BRF2
Target Full Name
Transcription factor IIIB 50 kDa subunit
Target Function
General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.
Target Subcellular Location
Nucleus.
Target Protein Families
TFIIB family
Target Synonyms
B-related factor 2; BRF-2; BRF2; BRF2_HUMAN; BRFU; FLJ11052; hBRFU; hTFIIIB50; RNA polymerase III transcription initiation factor BRF2; TFIIIB50; Transcription factor IIB- related factor TFIIIB50; Transcription factor IIIB 50 kDa subunit
Target Background
This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein.
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