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The antibody against CENPC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CENPC (NP_001803.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CENPC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CENPC (NP_001803.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02964A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CENPC |
| Target Synonyms | MIF2; hcp-4; CENP-C; CENPC1; CENPC | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, A-431, HepG2, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CENPC (NP_001803.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q03188 | Immunogen Sequence |
Uniprot Id
Q03188
Target Species
Human
Target Name
CENPC
Target Full Name
Centromere protein C
Target Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Target Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere.
Target Protein Families
CENP-C/MIF2 family
Target Synonyms
MIF2; hcp-4; CENP-C; CENPC1; CENPC
Target Background
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.
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