Rabbit anti-Human CHRNA9 Polyclonal Antibody

Uniprot Id

Q9UGM1

Target Species

Human

Target Name

CHRNA9

Target Full Name

Neuronal acetylcholine receptor subunit alpha-9

Target Function

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.

Target Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-9/CHRNA9 sub-subfamily

Target Tissue Specificity

Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.

Target Synonyms

CHRNA9; NACHRA9Neuronal acetylcholine receptor subunit alpha-9; Nicotinic acetylcholine receptor subunit alpha-9; NACHR alpha-9

Target Background

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea.