Rabbit anti-Human COPS2 Polyclonal Antibody

The antibody against COPS2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human COPS2 (NP_004227.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-02725A

Number

Cat.No	ADA-02725A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	COPS2
Target Synonyms	CSN2; SGN2; ALIEN; TRIP15; COPS2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, NIH/3T3, A-431, Jurkat, MCF7, Mouse brain, Mouse skeletal muscle	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-02725A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

COPS2

Target Synonyms

CSN2; SGN2; ALIEN; TRIP15; COPS2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, NIH/3T3, A-431, Jurkat, MCF7, Mouse brain, Mouse skeletal muscle

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human COPS2 (NP_004227.1).	Target Species	Human
Uniprot ID	P61201	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human COPS2 (NP_004227.1).

Target Species

Human

Uniprot ID

P61201

Immunogen Sequence

Background Information

Uniprot Id

P61201
Target Species

Human
Target Name

COPS2
Target Full Name

COP9 signalosome complex subunit 2
Target Function

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

CSN2 family
Target Research Area

Signal Transduction
Target Synonyms

ALIEN; Alien Drosophila himolog of; Alien homolog; COP 9; COP9; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; COPS 2; Cops2; CSN2; CSN2_HUMAN; JAB1 containing signalosome subunit 2; JAB1-containing signalosome subunit 2; SGN 2; SGN2; Signalosome subunit 2; Thyroid Hormone Receptor Interactor15; Thyroid Hormone Receptor Interactor 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP 15; TRIP-15; TRIP15
Target Background

Predicted to enable transcription corepressor activity. Involved in protein deneddylation and protein phosphorylation. Located in cytoplasm. Part of COP9 signalosome.

Rabbit anti-Human COPS2 Polyclonal Antibody

Specifications

Immunogen Information

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