Rabbit anti-Human DUSP5 Polyclonal Antibody

Uniprot Id

Q16690

Target Species

Human

Target Name

DUSP5

Target Full Name

Dual specificity protein phosphatase 5

Target Function

Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.

Target Subcellular Location

Nucleus.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily

Target Synonyms

Dual specificity phosphatase 5; Dual specificity protein phosphatase 5; Dual specificity protein phosphatase hVH 3; Dual specificity protein phosphatase hVH3; DUS5_HUMAN; DUSP 5; DUSP; DUSP5; HVH 3; HVH3; Serine/threonine specific protein phosphatase; VH 3; VH1 like phosphatase 3; VH3

Target Background

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.