Rabbit anti-Human EXOC2 Polyclonal Antibody

Uniprot Id

Q96KP1

Target Species

Human

Target Name

EXOC2

Target Full Name

Exocyst complex component 2

Target Function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Target Subcellular Location

Midbody, Midbody ring.

Target Protein Families

SEC5 family

Target Tissue Specificity

Widely expressed with highest levels in brain and placenta.

Target Synonyms

EXOC2; EXOC2_HUMAN; Exocyst complex component 2; Exocyst complex component Sec5; FLJ11026 ; SEC5; SEC5 like 1; SEC5L1; Sec5p

Target Background

The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants.