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The antibody against FKBP38/FKBP8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human FKBP38/FKBP38/FKBP8 (NP_036313.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.
The antibody against FKBP38/FKBP8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human FKBP38/FKBP38/FKBP8 (NP_036313.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.
| Cat.No | ADA-09381A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FKBP38/FKBP8 |
| Target Synonyms | FKBP38; FKBPr38; FKBP38/FKBP8 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, BT-474, HL-60, Jurkat, Mouse brain, Mouse eye, Mouse liver, THP-1 | Application | ELISA, WB, IF/ICC, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human FKBP38/FKBP38/FKBP8 (NP_036313.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q14318 | Immunogen Sequence |
Uniprot Id
Q14318
Target Species
Human
Target Name
FKBP8
Target Full Name
Peptidyl-prolyl cis-trans isomerase FKBP8
Target Function
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Target Subcellular Location
Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.; [Isoform 1]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.; [Isoform 3]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.
Target Tissue Specificity
Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.
Target Synonyms
FKBP8; FKBP38; Peptidyl-prolyl cis-trans isomerase FKBP8; PPIase FKBP8; 38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase
Target Background
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.
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