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The antibody against GAPVD1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human GAPVD1 (NP_056450.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against GAPVD1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human GAPVD1 (NP_056450.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-05944A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GAPVD1 |
| Target Synonyms | RAP6; GAPEX5; GAPex-5; GAPVD1 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, Mouse thymus | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human GAPVD1 (NP_056450.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q14C86 | Immunogen Sequence |
Uniprot Id
Q14C86
Target Species
Human
Target Name
GAPVD1
Target Full Name
GTPase-activating protein and VPS9 domain-containing protein 1
Target Function
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras
Target Subcellular Location
Membrane; Peripheral membrane protein. Endosome. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.
Target Protein Families
GAPVD1 family
Target Synonyms
GAPVD1; GAPEX5; KIAA1521; RAP6GTPase-activating protein and VPS9 domain-containing protein 1; GAPex-5; Rab5-activating protein 6
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