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The antibody against GCM1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human GCM1 (NP_003634.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against GCM1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human GCM1 (NP_003634.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
Immunofluorescence analysis of MCF-7 cells using GCM1 antibody. Blue: DAPI for nuclear staining.
| Cat.No | ADA-02592A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GCM1 |
| Target Synonyms | GCMA; hGCMa; GCM1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human GCM1 (NP_003634.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NP62 | Immunogen Sequence |
Uniprot Id
Q9NP62
Target Species
Human
Target Name
GCM1
Target Full Name
Chorion-specific transcription factor GCMa
Target Function
Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Highly expressed in the placenta. Expressed in trophoblast cells of the villi.
Target Synonyms
Chorion specific transcription factor GCMa; Chorion-specific transcription factor GCMa; GCM 1; GCM A; GCM motif protein 1; Gcm1; GCM1_HUMAN; Gcm1rs1; GCMA; Gcmrs2; Glial cells missing homolog 1; Glial cells missing homolog a; Glide; hGCMa
Target Background
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.
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