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The antibody against GPA33 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 220-319 of human GPA33 (Q99795) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against GPA33 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 220-319 of human GPA33 (Q99795) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-14163A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GPA33 |
| Target Synonyms | A33; GPA33 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A549, HCT 116, HT-29, Mouse stomach, Rat large intestine | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 220-319 of human GPA33 (Q99795). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | QFCNITVAVRSPSMNVALYVGIAVGVVAALIIIGIIIYCCCCRGKDDNTEDKEDARPNREAYEEPPEQLRELSREREEEDDYRQEEQRSTGRESPDHLDQ | Uniprot ID | Q99795 |
Uniprot Id
Q99795
Target Species
Human
Target Name
GPA33
Target Full Name
Cell surface A33 antigen
Target Function
May play a role in cell-cell recognition and signaling.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.
Target Synonyms
A33; Cell surface A33 antigen; Cell surface A33 antigen precursor; Glycoprotein A33 (transmembrane); Glycoprotein A33; Gpa33; GPA33_HUMAN; MGC129986; MGC129987; OTTHUMP00000032346; Transmembrane glycoprotein A33
Target Background
The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.
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