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The antibody against GTSE1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GTSE1 (NP_057510.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GTSE1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GTSE1 (NP_057510.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05954A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GTSE1 |
| Target Synonyms | B99; GTSE1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, LO2, Mouse spleen, Rat spleen, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GTSE1 (NP_057510.4). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NYZ3 | Immunogen Sequence |
Uniprot Id
Q9NYZ3
Target Species
Human
Target Name
GTSE1
Target Full Name
G2 and S phase-expressed protein 1
Target Function
May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.
Target Subcellular Location
Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Target Synonyms
GTSE1; G2 and S phase-expressed protein 1; GTSE-1; Protein B99 homolog
Target Background
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.
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