Rabbit anti-Human GUK1 Polyclonal Antibody

The antibody against GUK1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human GUK1 (NP_000849.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01134A

Number

Cat.No	ADA-01134A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	GUK1
Target Synonyms	GMK; GUK1	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	BT-474, Jurkat, LO2, SKOV3	Application	ELISA, WB

Cat.No

ADA-01134A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

GUK1

Target Synonyms

GMK; GUK1

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

BT-474, Jurkat, LO2, SKOV3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human GUK1 (NP_000849.1).	Target Species	Human
Immunogen Sequence	MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA	Uniprot ID	Q16774

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human GUK1 (NP_000849.1).

Target Species

Human

Immunogen Sequence

MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA

Uniprot ID

Q16774

Background Information

Uniprot Id

Q16774
Target Species

Human
Target Name

GUK1
Target Full Name

Guanylate kinase
Target Function

Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine.
Target Subcellular Location

Photoreceptor inner segment. Cytoplasm, cytosol.
Target Protein Families

Guanylate kinase family
Target Tissue Specificity

Widely expressed.
Target Research Area

Cancer
Target Synonyms

ATP:GMP phosphotransferase; FLJ42686; FLJ43710; GMK; GMP kinase; Guanylate kinase; GUK1; KGUA_HUMAN
Target Background

The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human GUK1 Polyclonal Antibody

Specifications

Immunogen Information

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