Rabbit anti-Human HES1 Monoclonal Antibody

The antibody against HES1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 181-280 of human HES1 (Q14469) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IP, ELISA.

ADA-17027A

Number

Cat.No	ADA-17027A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	HES1
Target Synonyms	HHL; HRY; HES-1; bHLHb39; HES1	Form	Liquid
Species Reactivity	Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse eye, Rat testis	Application	ELISA, WB, IHC-P, IP

Cat.No

ADA-17027A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

HES1

Target Synonyms

HHL; HRY; HES-1; bHLHb39; HES1

Form

Liquid

Species Reactivity

Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse eye, Rat testis

Application

ELISA, WB, IHC-P, IP

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 181-280 of human HES1 (Q14469).	Target Species	Human
Immunogen Sequence	FAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN	Uniprot ID	Q14469

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 181-280 of human HES1 (Q14469).

Target Species

Human

Immunogen Sequence

FAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN

Uniprot ID

Q14469

Background Information

Uniprot Id

Q14469
Target Species

Human
Target Name

HES1
Target Full Name

Transcription factor HES-1
Target Function

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Target Subcellular Location

Nucleus.
Target Synonyms

bHLHb39; C-HAIRY1; c-hairy1A; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1 (Drosophila); Hairy and enhancer of split 1; Hairy homolog (Drosophila); Hairy homolog; Hairy like ; Hairy, Drosophila, homolog of; Hairy-like protein; Hairy/enhancer of split, Drosophila, homolog of, 1; HAIRY1; HES-1; hes1; Hes1 hairy and enhancer of split 1 (Drosophila); HES1_HUMAN; HHL; HL; HRY; MGC129109; OTTHUMP00000209031; RHL; Transcription factor HES-1
Target Background

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

Rabbit anti-Human HES1 Monoclonal Antibody

Specifications

Immunogen Information

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