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The antibody against HIST1H1C was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 100-200 of human HIST1H1C (NP_005310.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against HIST1H1C was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 100-200 of human HIST1H1C (NP_005310.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using HIST1H1C Rabbit pAb at dilution of 1:200 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
| Cat.No | ADA-04141A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HIST1H1C |
| Target Synonyms | H1C; H1.2; H1F2; H1s-1; HIST1H1C | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HIST1H1C (NP_005310.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | GASGSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVAKPKKAAKSAAKAVKPKAAKP | Uniprot ID | P16403 |
Uniprot Id
P16403
Target Species
Human
Target Name
H1-2
Target Full Name
Histone H1.2
Target Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
Target Subcellular Location
Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
Target Protein Families
Histone H1/H5 family
Target Synonyms
H1 histone family member 2; H1.a; H12_HUMAN; H1F2; H1s-1; HIST1H1C; Histone 1 H1c; Histone cluster 1 H1c; Histone H1.2; Histone H1c; Histone H1d; Histone H1s-1; MGC3992
Target Background
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
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