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The antibody against HIST1H1C was raised in rabbit using the Synthesized peptide derived from Human Histone H1.2 protein (57-69aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against HIST1H1C was raised in rabbit using the Synthesized peptide derived from Human Histone H1.2 protein (57-69aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-54851A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HIST1H1C |
| Target Synonyms | H1F2, HIST1H1C, Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from Human Histone H1.2 protein (57-69aa) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P16403 |
Uniprot Id
P16403
Target Species
Human
Target Name
H1-2
Target Full Name
Histone H1.2
Target Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
Target Subcellular Location
Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
Target Protein Families
Histone H1/H5 family
Target Synonyms
H1 histone family member 2; H1.a; H12_HUMAN; H1F2; H1s-1; HIST1H1C; Histone 1 H1c; Histone cluster 1 H1c; Histone H1.2; Histone H1c; Histone H1d; Histone H1s-1; MGC3992
Target Background
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
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