Rabbit anti-Human HOXD10 Polyclonal Antibody

Uniprot Id

P28358

Target Species

Human

Target Name

HOXD10

Target Full Name

Homeobox protein Hox-D10

Target Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Target Involvement

Vertical talus, congenital (CVT)

Target Subcellular Location

Nucleus.

Target Protein Families

Abd-B homeobox family

Target Tissue Specificity

Strongly expressed in the adult male and female urogenital tracts.

Target Synonyms

AI385591; AI874987; Homeo box 4D; Homeo box D10 ; Homeobox D10; Homeobox protein Hox-4D; Homeobox protein Hox-4E; Homeobox protein Hox-D10; Hox 4.4; Hox 4.5; Hox 4D ; Hox 4E ; Hox 5.3; HOX4D ; HOX4E; HOXD10; HXD10; HXD10_HUMAN; OTTMUSP00000017845; RP23-313J15.9

Target Background

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.