Rabbit anti-Human HRH2 Polyclonal Antibody

The antibody against HRH2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 150-250 of human HRH2 (NP_001124527.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-10230A

Number

Cat.No	ADA-10230A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	HRH2
Target Synonyms	H2R; HH2R; HRH2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	A-431, LO2, Mouse skeletal muscle	Application	ELISA, WB

Cat.No

ADA-10230A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

HRH2

Target Synonyms

H2R; HH2R; HRH2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

A-431, LO2, Mouse skeletal muscle

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 150-250 of human HRH2 (NP_001124527.1).	Target Species	Human
Immunogen Sequence	SFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPY	Uniprot ID	P25021

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 150-250 of human HRH2 (NP_001124527.1).

Target Species

Human

Immunogen Sequence

SFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPY

Uniprot ID

P25021

Background Information

Uniprot Id

P25021
Target Species

Human
Target Name

HRH2
Target Full Name

Histamine H2 receptor
Target Function

The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway.
Target Subcellular Location

Cell membrane; Multi-pass membrane protein.
Target Protein Families

G-protein coupled receptor 1 family
Target Synonyms

HRH2; Histamine H2 receptor; H2R; HH2R; Gastric receptor I
Target Background

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human HRH2 Polyclonal Antibody

Specifications

Immunogen Information

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