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The antibody against KLB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 720-990 of human KLB (NP_783864.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against KLB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 720-990 of human KLB (NP_783864.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-12504A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KLB |
| Target Synonyms | BKL; KLB | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | LO2, Rat liver, SGC-7901 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 720-990 of human KLB (NP_783864.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q86Z14 | Immunogen Sequence |
Uniprot Id
Q86Z14
Target Species
Human
Target Name
KLB
Target Full Name
Beta-klotho
Target Function
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.
Target Subcellular Location
Cell membrane; Single-pass type III membrane protein.
Target Protein Families
Glycosyl hydrolase 1 family, Klotho subfamily
Target Synonyms
Beta-klotho; BetaKlotho; BKL; KLB; KLOTB_HUMAN; Klotho beta like protein; Klotho beta-like protein
Target Background
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum.
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