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The antibody against LIMCH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 150-450 of human LIMCH1 (NP_001106189.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against LIMCH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 150-450 of human LIMCH1 (NP_001106189.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10516A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LIMCH1 |
| Target Synonyms | LMO7B; LIMCH1A; LIMCH1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | LO2 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 150-450 of human LIMCH1 (NP_001106189.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UPQ0 | Immunogen Sequence |
Uniprot Id
Q9UPQ0
Target Species
Human
Target Name
LIMCH1
Target Full Name
LIM and calponin homology domains-containing protein 1
Target Function
Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.
Target Subcellular Location
Cytoplasm, cytoskeleton, stress fiber.
Target Protein Families
LIMCH1 family
Target Synonyms
DKFZp434I0312; DKFZp686A01247; DKFZp686B2470; DKFZp686G18243; DKFZp686G2094; DKFZp781C1754; DKFZp781I1455; KIAA1102; LIM and calponin homology domains 1; LIM and calponin homology domains containing protein 1; LIM and calponin homology domains-containing protein 1; LIMC1_HUMAN; LIMCH 1; limch1; LIMCH1A; LMO7B; MGC72127; OTTHUMP00000218619
Target Background
Enables myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in stress fiber. Colocalizes with myosin II complex.
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