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The antibody against MED18 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human MED18 (NP_001120822.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MED18 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human MED18 (NP_001120822.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10195A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MED18 |
| Target Synonyms | SRB5; p28b; MED18 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HT-29, Jurkat, Mouse liver, Mouse thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human MED18 (NP_001120822.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BUE0 | Immunogen Sequence |
Uniprot Id
Q9BUE0
Target Species
Human
Target Name
MED18
Target Full Name
Mediator of RNA polymerase II transcription subunit 18
Target Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Target Subcellular Location
Nucleus.
Target Protein Families
Mediator complex subunit 18 family
Target Synonyms
FLJ20045; hMED 18; hMED18; Human Mediator of RNA Polymerase II Transcription; MED 18; med18; MED18_HUMAN; Mediator complex subunit 18; Mediator of RNA polymerase II transcription subunit 18; Mediator of RNA polymerase II transcription subunit 18 homolog ; OTTHUMP00000003645; p28b; TRAP/mediator complex subunit p28b
Target Background
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).
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