Rabbit anti-Human Mesothelin Polyclonal Antibody

The antibody against Mesothelin was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 296-606 of human Mesothelin (NP_037536.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-05850A

Number

Cat.No	ADA-05850A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Mesothelin
Target Synonyms	MPF; SMRP; Mesothelin	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	OVCAR3	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-05850A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Mesothelin

Target Synonyms

MPF; SMRP; Mesothelin

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

OVCAR3

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 296-606 of human Mesothelin (NP_037536.2).	Target Species	Human
Uniprot ID	Q13421	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 296-606 of human Mesothelin (NP_037536.2).

Target Species

Human

Uniprot ID

Q13421

Immunogen Sequence

Background Information

Uniprot Id

Q13421
Target Species

Human
Target Name

MSLN
Target Full Name

Mesothelin
Target Function

Membrane-anchored forms may play a role in cellular adhesion.; Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Target Involvement

Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; [Megakaryocyte-potentiating factor]: Secreted.; [Isoform 3]: Secreted.
Target Protein Families

Mesothelin family
Target Tissue Specificity

Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
Target Research Area

Cancer
Target Synonyms

MPF; SMRP; Mesothelin
Target Background

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Rabbit anti-Human Mesothelin Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human Mesothelin Polyclonal Antibody Now

Related Products