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The antibody against MGP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-103 of human MGP (NP_000891.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against MGP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-103 of human MGP (NP_000891.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-03787A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MGP |
| Target Synonyms | NTI; GIG36; MGLAP; MGP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | SH-SY5Y | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-103 of human MGP (NP_000891.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | YESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGTK | Uniprot ID | P08493 |
Uniprot Id
P08493
Target Species
Human
Target Name
MGP
Target Full Name
Matrix Gla protein
Target Function
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Target Involvement
Keutel syndrome (KTLS)
Target Subcellular Location
Secreted.
Target Protein Families
Osteocalcin/matrix Gla protein family
Target Research Area
Developmental Biology, Signal Transduction
Target Synonyms
Cell growth inhibiting gene 36 protein; Cell growth-inhibiting gene 36 protein; GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX; GIG36; Matrix Gla protein; MGLAP; MGP; MGP_HUMAN; NTI
Target Background
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.
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