Rabbit anti-Human MXD1 Polyclonal Antibody

The antibody against MXD1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 100-200 of human MXD1 (NP_002348.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-04097A

Number

Cat.No	ADA-04097A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MXD1
Target Synonyms	MAD; MAD1; BHLHC58; MXD1	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	MCF7, Rat testis	Application	ELISA, WB

Cat.No

ADA-04097A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MXD1

Target Synonyms

MAD; MAD1; BHLHC58; MXD1

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

MCF7, Rat testis

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MXD1 (NP_002348.1).	Target Species	Human
Immunogen Sequence	KAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEG	Uniprot ID	Q05195

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MXD1 (NP_002348.1).

Target Species

Human

Immunogen Sequence

KAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEG

Uniprot ID

Q05195

Background Information

Uniprot Id

Q05195
Target Species

Human
Target Name

MXD1
Target Full Name

Max dimerization protein 1
Target Function

Component of a transcriptional repressor complex together with MAX. In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing with MYC for MAX binding. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
Target Subcellular Location

Nucleus.
Target Synonyms

MAD; MAD1; BHLHC58; MXD1
Target Background

This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Rabbit anti-Human MXD1 Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human MXD1 Polyclonal Antibody Now

Related Products