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The antibody against NCKAP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human NCKAP1 (NP_038464.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against NCKAP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human NCKAP1 (NP_038464.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02257A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NCKAP1 |
| Target Synonyms | HEM2; NAP1; NAP125; p125Nap1; NCKAP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Rat brain, HepG2, MCF7, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human NCKAP1 (NP_038464.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y2A7 | Immunogen Sequence |
Uniprot Id
Q9Y2A7
Target Species
Human
Target Name
NCKAP1
Target Full Name
Nck-associated protein 1
Target Function
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Target Subcellular Location
Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side.
Target Protein Families
HEM-1/HEM-2 family
Target Tissue Specificity
Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle. Expressed in cells of various brain regions including Purkinje cells and dentate nucleus of the cerebellum, CA4 region and
Target Synonyms
FLJ11291; KIAA0587; Membrane associated protein HEM2; Membrane-associated protein HEM-2; MGC8981; NAP 1; NAP1; NAP125; NCK associated protein 1; NCK associated protein; Nck-associated protein 1; Nckap1; NCKP1_HUMAN; OTTHUMP00000163460; OTTHUMP00000163461; p125Nap1
Target Background
Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular exosome and focal adhesion. Part of SCAR complex.
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