Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against NELFCD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 40-182 of human NELFCD (NP_945327.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against NELFCD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 40-182 of human NELFCD (NP_945327.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-06809A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NELFCD |
| Target Synonyms | TH1; TH1L; NELF-C; NELF-D; HSPC130; NELFCD | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, HCT116, Mouse testis, NCI-H460 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 40-182 of human NELFCD (NP_945327.3). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | HKFSTRDYIMEPSIFNTLKRYFQAGGSPENVIQLLSENYTAVAQTVNLLAEWLIQTGVEPVQVQETVENHLKSLLIKHFDPRKADSIFTEEGETPAWLEQMIAHTTWRDLFYKLAEAHPDCLMLNFTVKLISDAGYQGEITSV | Uniprot ID | Q8IXH7 |
Uniprot Id
Q8IXH7
Target Species
Human
Target Name
NELFCD
Target Full Name
Negative elongation factor C/D
Target Function
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
Target Subcellular Location
Nucleus.
Target Protein Families
NELF-D family
Target Tissue Specificity
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.
Target Synonyms
TH1; TH1L; NELF-C; NELF-D; HSPC130; NELFCD
Target Background
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
