Rabbit anti-Human NKX3-2 Polyclonal Antibody

The antibody against NKX3-2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human NKX3-2 (NP_001180.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01787A

Number

Cat.No	ADA-01787A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	NKX3-2
Target Synonyms	SMMD; BAPX1; NKX3B; NKX3.2; NKX3-2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T transfected with NKX3-2, Mouse spleen	Application	ELISA, WB

Cat.No

ADA-01787A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

NKX3-2

Target Synonyms

SMMD; BAPX1; NKX3B; NKX3.2; NKX3-2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T transfected with NKX3-2, Mouse spleen

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human NKX3-2 (NP_001180.1).	Target Species	Human
Immunogen Sequence	MAVRGANTLTSFSIQAILNKKEERGGLAAPEGRPAPGGTAASVAAAPAVCCWRLFGERDAGALGGAEDSLLASPAGTRTAAGRTAESPEGWDSDSALSEENESRRRCADARGASGAGLAGGSLSLGQPVCELAASKDLEEEAAGRSDSEMSASVSGDRSPRTEDDGVGPRGAHVSALCSG	Uniprot ID	P78367

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human NKX3-2 (NP_001180.1).

Target Species

Human

Immunogen Sequence

MAVRGANTLTSFSIQAILNKKEERGGLAAPEGRPAPGGTAASVAAAPAVCCWRLFGERDAGALGGAEDSLLASPAGTRTAAGRTAESPEGWDSDSALSEENESRRRCADARGASGAGLAGGSLSLGQPVCELAASKDLEEEAAGRSDSEMSASVSGDRSPRTEDDGVGPRGAHVSALCSG

Uniprot ID

P78367

Background Information

Uniprot Id

P78367
Target Species

Human
Target Name

NKX3-2
Target Full Name

Homeobox protein Nkx-3.2
Target Function

Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
Target Involvement

Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD)
Target Subcellular Location

Nucleus.
Target Protein Families

NK-3 homeobox family
Target Tissue Specificity

Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

Bagpipe homeobox 1; Bagpipe homeobox homolog 1; Bagpipe homeobox protein homolog 1; Bagpipe homeobox; Drosophila; homolog of; 1; BAPX 1; Homeobox protein NK-3 homolog B; Homeobox protein Nkx 3.2; Homeobox protein Nkx-3.2; MGC138171; NK3 homeobox 2; NKX3 2; NKX3-2; NKX3.2; NKX3.2; mouse; homolog of; NKX32_HUMAN; NKX3B; OTTHUMP00000115816; SMMD
Target Background

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation; negative regulation of chondrocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; embryonic skeletal system development; and intestinal epithelial cell development. Predicted to be part of chromatin. Predicted to be active in nucleus.

Rabbit anti-Human NKX3-2 Polyclonal Antibody

Specifications

Immunogen Information

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